USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P54578 USC-OGP 2-DE database:  P54578 P54578 General information about the entry View entry in simple text format Entry name UBP14_HUMAN Primary accession number P54578 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Ubiquitin carboxyl-terminal hydrolase 14; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme 14; AltName: Full=Ubiquitin thioesterase 14; AltName: Full=Ubiquitin-specific-processing protease 14;. Gene name Name=USP14 Synonyms=TGT Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0656: pI=5.20; Mw=54807 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1133: pI=5.37; Mw=64830 Cross-references UniProtKB/Swiss-Prot P54578; UBP14_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name UBP14_HUMAN Primary accession number P54578 Secondary accession number(s) B7Z4N8 J3QRZ5 Q53XY5 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 168) Name and origin of the protein Description RecName: Full=Ubiquitin carboxyl-terminal hydrolase 14; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme 14; AltName: Full=Ubiquitin thioesterase 14; AltName: Full=Ubiquitin-specific-processing protease 14; Gene name Name=USP14 Synonyms=TGT Encoded on Name=USP14; Synonyms=TGT Keywords 3D-structure; Acetylation; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Hydrolase; Membrane; Phosphoprotein; Protease; Proteasome; Reference proteome; Thiol protease; Ubl conjugation pathway. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U30888; AAB60365.1; -; mRNA EMBL BT007183; AAP35847.1; -; mRNA EMBL AK297605; BAH12624.1; -; mRNA EMBL AP000845; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC003556; AAH03556.1; -; mRNA EMBL CR976282; -; NOT_ANNOTATED_CDS; mRNA CCDS CCDS32780.1; -. [P54578-1]; . CCDS CCDS32781.1; -. [P54578-2]; . PIR G01932; G01932; . RefSeq NP_001032411.1; NM_001037334.1. [P54578-2]; . RefSeq NP_005142.1; NM_005151.3. [P54578-1]; . UniGene Hs.464416; -; . UniGene Hs.707058; -; . PDB 2AYN; X-ray; 3.20 A; A/B/C=91-494 PDB 2AYO; X-ray; 3.50 A; A=91-494 PDB 5GJQ; EM; 4.50 A; x=1-494 PDBsum 2AYN; -; . PDBsum 2AYO; -; . PDBsum 5GJQ; -; . ProteinModelPortal P54578; -; . SMR P54578; -; . BioGrid 114551; 73; . IntAct P54578; 32; . MINT MINT-3020275; -; . STRING 9606.ENSP00000261601; -; . BindingDB P54578; -; . ChEMBL CHEMBL1293295; -; . GuidetoPHARMACOLOGY 2429; -; . MEROPS C19.015; -; . iPTMnet P54578; -; . PhosphoSitePlus P54578; -; . SwissPalm P54578; -; . BioMuta USP14; -; . DMDM 1729927; -; . OGP P54578; -; . EPD P54578; -; . MaxQB P54578; -; . PaxDb P54578; -; . PeptideAtlas P54578; -; . PRIDE P54578; -; . DNASU 9097; -; . Ensembl ENST00000261601; ENSP00000261601; ENSG00000101557. [P54578-1]; . Ensembl ENST00000400266; ENSP00000383125; ENSG00000101557. [P54578-3]; . Ensembl ENST00000582707; ENSP00000464447; ENSG00000101557. [P54578-2]; . GeneID 9097; -; . KEGG hsa:9097; -; . UCSC uc002kkf.2; human. [P54578-1]; . CTD 9097; -; . DisGeNET 9097; -; . GeneCards USP14; -; . HGNC HGNC:12612; USP14; . HPA HPA001308; -; . MIM 607274; gene; . neXtProt NX_P54578; -; . OpenTargets ENSG00000101557; -; . PharmGKB PA37238; -; . eggNOG KOG1872; Eukaryota; . eggNOG ENOG410XP96; LUCA; . GeneTree ENSGT00390000009615; -; . HOGENOM HOG000202292; -; . HOVERGEN HBG054185; -; . InParanoid P54578; -; . KO K11843; -; . OMA FKVKVKW; -; . OrthoDB EOG091G06MR; -; . PhylomeDB P54578; -; . TreeFam TF314494; -; . Reactome R-HSA-5689880; Ub-specific processing proteases; . ChiTaRS USP14; human; . EvolutionaryTrace P54578; -; . GeneWiki USP14; -; . GenomeRNAi 9097; -; . PRO PR:P54578; -; . Proteomes UP000005640; Chromosome 18; . Bgee ENSG00000101557; -; . CleanEx HS_USP14; -; . ExpressionAtlas P54578; baseline and differential; . Genevisible P54578; HS; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; . GO GO:0000502; C:proteasome complex; IEA:UniProtKB-KW; . GO GO:0045202; C:synapse; IEA:Ensembl; . GO GO:0004197; F:cysteine-type endopeptidase activity; TAS:ProtInc; . GO GO:0004866; F:endopeptidase inhibitor activity; IMP:UniProtKB; . GO GO:0070628; F:proteasome binding; IDA:UniProtKB; . GO GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IDA:FlyBase; . GO GO:0008193; F:tRNA guanylyltransferase activity; TAS:ProtInc; . GO GO:0007268; P:chemical synaptic transmission; IEA:Ensembl; . GO GO:1903070; P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process; IMP:ParkinsonsUK-UCL; . GO GO:0016579; P:protein deubiquitination; IDA:FlyBase; . GO GO:0050920; P:regulation of chemotaxis; IMP:UniProtKB; . GO GO:0061136; P:regulation of proteasomal protein catabolic process; IMP:UniProtKB; . GO GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro; . InterPro IPR001394; Peptidase_C19_UCH; . InterPro IPR029071; Ubiquitin-rel_dom; . InterPro IPR019954; Ubiquitin_CS; . InterPro IPR000626; Ubiquitin_dom; . InterPro IPR018200; USP_CS; . InterPro IPR028889; USP_dom; . Pfam PF00443; UCH; 1; . SMART SM00213; UBQ; 1; . SUPFAM SSF54236; SSF54236; 1; . PROSITE PS00299; UBIQUITIN_1; 1; . PROSITE PS50053; UBIQUITIN_2; 1; . PROSITE PS00972; USP_1; 1; . PROSITE PS00973; USP_2; 1; . PROSITE PS50235; USP_3; 1; .

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